PhD Scholarship – High Order Chromatin Structure and Oncogenic Stress – University of Cambridge

Scholarship Description: Cancer Research UK Cambridge Institute (CRUK CI) is a joint venture between the Cancer Research UK charity and the University of Cambridge. The institute has excellent state-of-the-art facilities and research areas ranging from basic cancer biology and computational biology to translational research and clinical applications. PhD students play a central role in the continued success of our research programs, and a fellowship from the Institute is a great opportunity to embark on a research career in an environment committed to developing outstanding researchers in tomorrow’s oncology. Professor Masashi Narita would like to nominate a student for the project entitled: Higher Order Chromatin Structure and Oncogenic Stress. Project description: Low concentrations of oncogenic RAS promote proliferation, while high concentrations induce senescence. This nonlinear effect of RAS on cell proliferation suggests that there is a “tipping point” for induction of senescence. We recently discovered that oncogenes-induced senescence is accompanied by a drastic rewiring of the enhancer-promoter landscape (BioRxive). We hypothesize that changes in the dynamic and plastic landscape of the higher order chromatin structure could determine the oncogenic tipping point. We pursue this question with cell biological and genomic approaches (Hi-C, ChIP-seq etc.) as well as in close cooperation with computer biologists. Degree: Doctoral Scholarship – High Order Chromatin Structure and Oncogenic Stress – The University of Cambridge is available for doctoral programs at the University of Cambridge. Available Subjects: The following subjects are available as part of this scholarship program. Oncology high order chromatin structure
Scholarship Benefits: This project is funded by a Cancer Research UK Scholarship which includes full funding of university and college fees as well as a grant of £ 19,000 per year. Eligible Nationalities: There are no nationality restrictions on fellowships funded by Cancer Research UK. Applications are invited from graduates or final year students who have or are planning an upper first / second grade (or equivalent) degree in a relevant subject from an accredited university around the world. Eligibility Criterion: To be eligible, applicants must meet the following eligibility criteria: Graduates or final year students who have or wish to obtain a first or second degree (or equivalent) in a relevant subject from a recognized university in the world.

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